| 1 | Oppenheimer | J. Robert Oppenheimer ▸ Oppenheimer (film) | 6.3M | 56% | Contested |
| 2 | Big Bang | Big Bang ▸ The Big Bang Theory | 3.3M | 71% | Duplicate dominant |
| 3 | Apollo | Apollo (god) ▸ Apollo program | 3.1M | 58% | Contested |
| 4 | Artemis | Artemis (goddess) ▸ Artemis program | 3.1M | 54% | Contested |
| 5 | Quantum | Quantum mechanics ▸ Quantum computing | 1.7M | 47% | Contested |
| 6 | Saturn | Saturn (mythology) ▸ Saturn (planet) | 1.7M | 77% | Duplicate dominant |
| 7 | Venus | Venus (mythology) ▸ Venus (planet) | 1.6M | 78% | Duplicate dominant |
| 8 | Mars | Mars (mythology) ▸ Mars (planet) | 1.5M | 83% | Duplicate dominant |
| 9 | Mercury | Mercury (mythology) ▸ Mercury (planet) | 1.2M | 82% | Duplicate dominant |
| 10 | Pluto | Pluto (mythology) ▸ Pluto (dwarf planet) | 1.2M | 98% | Duplicate dominant |
| 11 | Neptune | Neptune (mythology) ▸ Neptune (planet) | 1.2M | 85% | Duplicate dominant |
| 12 | Gravity | Gravity ▸ Gravity (film) | 1.1M | 53% | Contested |
| 13 | Cell | Cell (biology) ▸ Mobile phone | 1.0M | 48% | Contested |
| 14 | Entropy | Entropy (thermodynamics) ▸ Entropy (information theory) | 1.0M | 35% | Original holds |
| 15 | Starship | Starship (science fiction) ▸ SpaceX Starship | 1.0M | 91% | Duplicate dominant |
| 16 | Dragon | Dragon (mythology) ▸ SpaceX Dragon | 807K | 7% | Original holds |
| 17 | Webb | James E. Webb ▸ James Webb Space Telescope | 753K | 86% | Duplicate dominant |
| 18 | Hubble | Edwin Hubble ▸ Hubble Space Telescope | 714K | 78% | Duplicate dominant |
| 19 | Ozempic | Semaglutide ▸ Ozempic face | 704K | — | — |
| 20 | Falcon | Falcon (bird) ▸ Falcon 9 | 664K | 52% | Contested |
| 21 | Mole | Mole (animal) ▸ Mole (unit) | 617K | 45% | Contested |
| 22 | Atlas | Atlas (mythology) ▸ Atlas (robot) | 612K | 8% | Original holds |
| 23 | Plasma | Blood plasma ▸ Plasma (physics) | 596K | 77% | Duplicate dominant |
| 24 | Nebula | Nebula ▸ Nebula (streaming) | 446K | 28% | Original holds |
| 25 | CRISPR | CRISPR (bacterial immunity) ▸ CRISPR gene editing | 429K | 33% | Original holds |
| 26 | Satellite | Satellite (moon) ▸ Artificial satellite | 427K | 60% | Duplicate dominant |
| 27 | Delta | Delta (letter) ▸ SARS-CoV-2 Delta variant | 357K | 9% | Original holds |
| 28 | Pulsar | Pulsar ▸ Apache Pulsar | 327K | — | — |
| 29 | Corona | Corona (sun) ▸ Coronavirus | 287K | 86% | Duplicate dominant |
| 30 | Rover | Rover (wanderer) ▸ Mars rover | 235K | 96% | Duplicate dominant |
| 31 | Eclipse | Eclipse ▸ Eclipse (IDE) | 213K | 36% | Original holds |
| 32 | Omicron | Omicron (letter) ▸ SARS-CoV-2 Omicron variant | 138K | 56% | Contested |
| 33 | Genome | Genome ▸ Genome (software) | 96K | — | — |
| 34 | Lander | Landowner ▸ Lander (spacecraft) | 58K | 43% | Contested |